Endocrine Abstracts

Reproductive activity of male Rhabdomys pumilio is inhibited by exposure to a combination of reduced ambient temperature and food availability. However, the extent of this inhibition is reduced in mice that have maintained a body fat reserve. To determine if body fat stimulates reproduction via leptin, we treated 5 non-scrotal mice with exogenous leptin (40 micrograms subcutaneously twice per day for four days). A further 5 mice served as untreated controls. To determin...

X-linked IGSF1 (immunoglobulin superfamily, member 1) loss-of-function mutations in males are associated with central hypothyroidism, macroorchidism, and a variable spectrum of anterior pituitary dysfunction. Igsf1 deficient male mice also exhibit central hypothyroidism, however, the physiological and molecular function of IGSF1 in both species has not yet been elucidated. Although partial transient GH deficiency is a ra...

X-linked IGSF1 (immunoglobulin superfamily, member 1) loss-of-function mutations in males are associated with central hypothyroidism, macroorchidism, and a variable spectrum of anterior pituitary dysfunction. Igsf1 deficient male mice also exhibit central hypothyroidism, however, the physiological and molecular function of IGSF1 in both species has not yet been elucidated. Although partial transient GH deficiency is a ra...